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Ex vivo-expanded human CD19(+)TIM-1(+) regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis
Regulatory B cells (Breg) are a heterogenous population with immune-modulating functions. The rarity of human IL-10(+) Breg makes translational studies difficult. Here we report ex vivo expansion of human B cells with in vivo regulatory function (expBreg). CD154-stimulation of human CD19(+) B cells...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166804/ https://www.ncbi.nlm.nih.gov/pubmed/35660734 http://dx.doi.org/10.1038/s41467-022-30613-z |