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RNF219 regulates CCR4-NOT function in mRNA translation and deadenylation

Post-transcriptional regulatory mechanisms play a role in many biological contexts through the control of mRNA degradation, translation and localization. Here, we show that the RING finger protein RNF219 co-purifies with the CCR4-NOT complex, the major mRNA deadenylase in eukaryotes, which mediates...

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Detalles Bibliográficos
Autores principales: Guénolé, Aude, Velilla, Fabien, Chartier, Aymeric, Rich, April, Carvunis, Anne-Ruxandra, Sardet, Claude, Simonelig, Martine, Sobhian, Bijan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166816/
https://www.ncbi.nlm.nih.gov/pubmed/35660762
http://dx.doi.org/10.1038/s41598-022-13309-8