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Glycation of α-synuclein hampers its binding to synaptic-like vesicles and its driving effect on their fusion
Parkinson’s disease (PD) is one of the most prevalent neurodegenerative disorders affecting the worldwide population. One of its hallmarks is the intraneuronal accumulation of insoluble Lewy bodies (LBs), which cause the death of dopaminergic neurons. α-Synuclein (αS) is the main component of these...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167179/ https://www.ncbi.nlm.nih.gov/pubmed/35662377 http://dx.doi.org/10.1007/s00018-022-04373-4 |