Glucosylceramide synthase inhibition protects against cardiac hypertrophy in chronic kidney disease

A significant population of patients with chronic kidney disease (CKD) develops cardiac hypertrophy, which can lead to heart failure and sudden cardiac death. Soluble klotho (sKL), the shed ectodomain of the transmembrane protein klotho, protects the heart against hypertrophic growth. We have shown...

Descripción completa

Detalles Bibliográficos
Autores principales: Baccam, Gabriel C., Xie, Jian, Jin, Xin, Park, Hyejung, Wang, Bing, Husson, Hervé, Ibraghimov-Beskrovnaya, Oxana, Huang, Chou-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167280/
https://www.ncbi.nlm.nih.gov/pubmed/35660779
http://dx.doi.org/10.1038/s41598-022-13390-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167280/
https://www.ncbi.nlm.nih.gov/pubmed/35660779
http://dx.doi.org/10.1038/s41598-022-13390-z

Ejemplares similares