Non-covalent Fc-Fab interactions significantly alter internal dynamics of an IgG1 antibody

The fragment-antigen-binding arms (Fab1 and Fab2) in a canonical immunoglobulin G (IgG) molecule have identical sequences and hence are always expected to exhibit symmetric conformations and dynamics. Using long all atom molecular simulations of a human IgG1 crystal structure 1HZH, we demonstrate th...

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Detalles Bibliográficos
Autores principales: Natesan, Ramakrishnan, Agrawal, Neeraj J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167292/
https://www.ncbi.nlm.nih.gov/pubmed/35661134
http://dx.doi.org/10.1038/s41598-022-13370-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167292/
https://www.ncbi.nlm.nih.gov/pubmed/35661134
http://dx.doi.org/10.1038/s41598-022-13370-3

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