Cargando…
Non-covalent Fc-Fab interactions significantly alter internal dynamics of an IgG1 antibody
The fragment-antigen-binding arms (Fab1 and Fab2) in a canonical immunoglobulin G (IgG) molecule have identical sequences and hence are always expected to exhibit symmetric conformations and dynamics. Using long all atom molecular simulations of a human IgG1 crystal structure 1HZH, we demonstrate th...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167292/ https://www.ncbi.nlm.nih.gov/pubmed/35661134 http://dx.doi.org/10.1038/s41598-022-13370-3 |