Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies

The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important target for vaccine and drug development. However, the rapid emergence of variant strains with mutated S proteins has rendered many treatments ineffective. Cleavage of the S protein by host proteases...

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Detalles Bibliográficos
Autores principales: Zhao, Miao-Miao, Zhu, Yun, Zhang, Li, Zhong, Gongxun, Tai, Linhua, Liu, Shuo, Yin, Guoliang, Lu, Jing, He, Qiong, Li, Ming-Jia, Zhao, Ru-Xuan, Wang, Hao, Huang, Weijin, Fan, Changfa, Shuai, Lei, Wen, Zhiyuan, Wang, Chong, He, Xijun, Chen, Qiuluan, Liu, Banghui, Xiong, Xiaoli, Bu, Zhigao, Wang, Youchun, Sun, Fei, Yang, Jin-Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167920/
https://www.ncbi.nlm.nih.gov/pubmed/35668062
http://dx.doi.org/10.1038/s41421-022-00419-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167920/
https://www.ncbi.nlm.nih.gov/pubmed/35668062
http://dx.doi.org/10.1038/s41421-022-00419-w

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