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HLA-I-restricted CD8(+) T cell immunity may accelerate tumorigenesis in conjunction with VHL inactivation
CD8(+) T cells recognize and kill tumor cells with HLA-I tumor antigens in early tumorigenesis, the efficiency of which differs according to antigen-recognition coverage, as shown in earlier tumor onset in HLA-I homozygosity. However, the universality of these associations remains unknown. Here, we...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167969/ https://www.ncbi.nlm.nih.gov/pubmed/35677644 http://dx.doi.org/10.1016/j.isci.2022.104467 |