Cargando…
Doxorubicin-induced hepatic toxicity in rats: Mechanistic protective role of Omega-3 fatty acids through Nrf2/HO-1 activation and PI3K/Akt/GSK-3β axis modulation
Doxorubicin (DOX), a common antibiotic used to treat a variety of tumors, has several substantial adverse effects that limit its clinical use. As a result, finding effective protective agents to combat DOX-induced organ damage is a necessity. The current study was set to delineate the hepatoprotecti...
Autores principales: | Saleh, Dalia O., Mahmoud, Sawsan S., Hassan, Azza, Sanad, Eman F. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167977/ https://www.ncbi.nlm.nih.gov/pubmed/35677895 http://dx.doi.org/10.1016/j.sjbs.2022.103308 |
Ejemplares similares
-
Omega-3 fatty acids ameliorate doxorubicin-induced cardiorenal toxicity: In-vivo regulation of oxidative stress, apoptosis and renal Nox4, and in-vitro preservation of the cytotoxic efficacy
por: Saleh, Dalia, et al.
Publicado: (2020) -
Asafoetida exerts neuroprotective effect on oxidative stress induced apoptosis through PI3K/Akt/GSK3β/Nrf2/HO-1 pathway
por: Huang, Qianqian, et al.
Publicado: (2022) -
Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
por: Kandezi, Niyoosha, et al.
Publicado: (2020) -
Piperine improves the sensitivity of osteosarcoma cells to doxorubicin by inducing apoptosis and inhibiting the PI3K/AKT/GSK-3β pathway
por: Qi, Yubin, et al.
Publicado: (2023) -
Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses
por: Matsuda, Satoru, et al.
Publicado: (2019)