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Genomic and Transcriptomic Analysis of Neuroendocrine Transformation in ALK-Rearranged Lung Adenocarcinoma After Treatments With Sequential ALK Inhibitors: A Brief Report

INTRODUCTION: Neuroendocrine (NE) transformation has been reported in patients with ALK-rearranged NSCLC after ALK inhibition, but unlike EGFR-mutant NSCLC, the exact mechanism of NE transformation in ALK-rearranged NSCLC is poorly studied. METHODS: We collected the matched pre- and post-transformat...

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Detalles Bibliográficos
Autores principales: Huang, Jie, Zhang, Shi-Ling, Zhou, Chaozheng, Huang, Weiye, Luo, Peng, Chen, Hua-Jun, Yang, Jin-Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168149/
https://www.ncbi.nlm.nih.gov/pubmed/35677682
http://dx.doi.org/10.1016/j.jtocrr.2022.100338