An allosteric HTRA1-calpain 2 complex with restricted activation profile

Zymogen activation is a widely conserved regulatory principle across protease clans. It describes the irreversible activation by processing of the inactive zymogen precursor by an active protease. Here we report an alternative and reversible mechanism of protease activation, where the activator is a...

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Detalles Bibliográficos
Autores principales: Rey, Juliana, Breiden, Maike, Lux, Vanda, Bluemke, Anika, Steindel, Maike, Ripkens, Kamilla, Möllers, Bastian, Bravo Rodriguez, Kenny, Boisguerin, Prisca, Volkmer, Rudolf, Mieres-Perez, Joel, Clausen, Tim, Sanchez-Garcia, Elsa, Ehrmann, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168489/
https://www.ncbi.nlm.nih.gov/pubmed/35349341
http://dx.doi.org/10.1073/pnas.2113520119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168489/
https://www.ncbi.nlm.nih.gov/pubmed/35349341
http://dx.doi.org/10.1073/pnas.2113520119

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