Sensitization of Non-Small Cell Lung Cancer Cells to Gefitinib and Reversal of Epithelial–Mesenchymal Transition by Aloe-Emodin Via PI3K/Akt/TWIS1 Signal Blockage

OBJECTIVE: To explore the impacts of AE (aloe-emodin) in gefitinib-resistant NSCLC (non-small cell lung cancer) cells and the corresponding mechanism. METHODS: PC9 and PC9-GR cells were cultured and treated by gefitinib, AE, or the combination of the two drugs. Then, viability, apoptosis, migration...

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Detalles Bibliográficos
Autores principales: Peng, Minghui, Zheng, Zhuifeng, Chen, Shaoyang, Fang, Le, Feng, Rongxiu, Zhang, Lijun, Tang, Qingnan, Liu, Xuewen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168594/
https://www.ncbi.nlm.nih.gov/pubmed/35677158
http://dx.doi.org/10.3389/fonc.2022.908031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168594/
https://www.ncbi.nlm.nih.gov/pubmed/35677158
http://dx.doi.org/10.3389/fonc.2022.908031

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