BRCA1 haploinsufficiency promotes chromosomal amplification under Fenton reaction-based carcinogenesis through ferroptosis-resistance

Germline-mutation in BRCA1 tumor suppressor gene is an established risk for carcinogenesis not only in females but also in males. Deficiency in the repair of DNA double-strand breaks is hypothesized as a responsible mechanism for carcinogenesis. However, supporting data is insufficient both in the m...

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Detalles Bibliográficos
Autores principales: Kong, Yingyi, Akatsuka, Shinya, Motooka, Yashiro, Zheng, Hao, Cheng, Zhen, Shiraki, Yukihiro, Mashimo, Tomoji, Imaoka, Tatsuhiko, Toyokuni, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168618/
https://www.ncbi.nlm.nih.gov/pubmed/35667247
http://dx.doi.org/10.1016/j.redox.2022.102356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168618/
https://www.ncbi.nlm.nih.gov/pubmed/35667247
http://dx.doi.org/10.1016/j.redox.2022.102356

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