Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion

OBJECTIVE: The prostate is metabolically unique: it produces high levels of citrate for secretion via a truncated tricarboxylic acid (TCA) cycle to maintain male fertility. In prostate cancer (PCa), this phenotype is reprogrammed, making it an interesting therapeutic target. However, how the truncat...

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Detalles Bibliográficos
Autores principales: Frégeau-Proulx, Lilianne, Lacouture, Aurélie, Berthiaume, Line, Weidmann, Cindy, Harvey, Mario, Gonthier, Kevin, Pelletier, Jean-François, Neveu, Bertrand, Jobin, Cynthia, Bastien, Dominic, Bergeron, Alain, Fradet, Yves, Lacombe, Louis, Laverdière, Isabelle, Atallah, Chantal, Pouliot, Frédéric, Audet-Walsh, Étienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168698/
https://www.ncbi.nlm.nih.gov/pubmed/35598879
http://dx.doi.org/10.1016/j.molmet.2022.101516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168698/
https://www.ncbi.nlm.nih.gov/pubmed/35598879
http://dx.doi.org/10.1016/j.molmet.2022.101516

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