Cargando…

Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion

OBJECTIVE: The prostate is metabolically unique: it produces high levels of citrate for secretion via a truncated tricarboxylic acid (TCA) cycle to maintain male fertility. In prostate cancer (PCa), this phenotype is reprogrammed, making it an interesting therapeutic target. However, how the truncat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frégeau-Proulx, Lilianne, Lacouture, Aurélie, Berthiaume, Line, Weidmann, Cindy, Harvey, Mario, Gonthier, Kevin, Pelletier, Jean-François, Neveu, Bertrand, Jobin, Cynthia, Bastien, Dominic, Bergeron, Alain, Fradet, Yves, Lacombe, Louis, Laverdière, Isabelle, Atallah, Chantal, Pouliot, Frédéric, Audet-Walsh, Étienne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168698/ https://www.ncbi.nlm.nih.gov/pubmed/35598879 http://dx.doi.org/10.1016/j.molmet.2022.101516

Ejemplares similares

Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic–mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer
por: Gonthier, Kevin, et al.
Publicado: (2023)

FACS-Free isolation and purification protocol of mouse prostate epithelial cells for organoid primary culture
por: Frégeau-Proulx, Lilianne, et al.
Publicado: (2022)

A FACS-Free Purification Method to Study Estrogen Signaling, Organoid Formation, and Metabolic Reprogramming in Mammary Epithelial Cells
por: Lacouture, Aurélie, et al.
Publicado: (2021)

Determiners of cell fates: the tricarboxylic acid cycle versus the citrate-malate shuttle
por: Guo, Dong, et al.
Publicado: (2022)

Subversion of infiltrating prostate macrophages to a mixed immunosuppressive tumor‐associated macrophage phenotype
por: Boibessot, Clovis, et al.
Publicado: (2022)

Association of the malate dehydrogenase-citrate synthase metabolon is modulated by intermediates of the Krebs tricarboxylic acid cycle
por: Omini, Joy, et al.
Publicado: (2021)

Application of citrate as a tricarboxylic acid (TCA) cycle intermediate, prevents diabetic-induced heart damages in mice
por: Liang, Qianqian, et al.
Publicado: (2016)

Tricarboxylate Citrate Transporter of an Oleaginous Fungus Mucor circinelloides WJ11: From Function to Structure and Role in Lipid Production
por: Yang, Wu, et al.
Publicado: (2021)

A PCA3 gene-based transcriptional amplification system targeting primary prostate cancer
por: Neveu, Bertrand, et al.
Publicado: (2015)

Corrigendum: Bioluminescence Microscopy as a Method to Measure Single Cell Androgen Receptor Activity Heterogeneous Responses to Antiandrogens
por: Jain, Pallavi, et al.
Publicado: (2016)

Bioluminescence Microscopy as a Method to Measure Single Cell Androgen Receptor Activity Heterogeneous Responses to Antiandrogens
por: Jain, Pallavi, et al.
Publicado: (2016)

Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway
por: Ren, Jian-Guo, et al.
Publicado: (2017)

Effects of omega‐3 supplementation on psychological symptoms in men with prostate cancer: Secondary analysis of a double‐blind placebo‐controlled randomized trial
por: Savard, Josée, et al.
Publicado: (2023)

IL-8 secretion in primary cultures of prostate cells is associated with prostate cancer aggressiveness
por: Neveu, Bertrand, et al.
Publicado: (2014)

Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hydroxypropane-1,2,3-tricarboxylate)
por: Morjan, Rami Y., et al.
Publicado: (2018)

Branched Tricarboxylic Acid Metabolism in Plasmodium falciparum
por: Olszewski, Kellen L., et al.
Publicado: (2010)

Regulation and function of the mammalian tricarboxylic acid cycle
por: Arnold, Paige K., et al.
Publicado: (2022)

Is there an impact of feet position on squatting birth position? An innovative biomechanical pilot study
por: Desseauve, David, et al.
Publicado: (2019)

FDG-PET/CT for pre-operative staging and prognostic stratification of patients with high-grade prostate cancer at biopsy
por: Beauregard, Jean-Mathieu, et al.
Publicado: (2015)

High infiltration of CD209(+) dendritic cells and CD163(+) macrophages in the peritumor area of prostate cancer is predictive of late adverse outcomes
por: Molina, Oscar Eduardo, et al.
Publicado: (2023)

The Role of Tricarboxylic Acid Cycle Metabolites in Viral Infections
por: Sánchez-García, Francisco Javier, et al.
Publicado: (2021)

Involvement of Tricarboxylic Acid Cycle Metabolites in Kidney Diseases
por: Jiménez-Uribe, Alexis Paulina, et al.
Publicado: (2021)

Optical Properties of Tricarboxylic Acid-Derived Carbon Dots
por: Tomskaya, Aleksandra, et al.
Publicado: (2022)

Identification of Noise Covariance Matrices to Improve Orientation Estimation by Kalman Filter
por: Nez, Alexis, et al.
Publicado: (2018)

Elongated and substituted triazine-based tricarboxylic acid linkers for MOFs
por: Klinkebiel, Arne, et al.
Publicado: (2016)

Tricarboxylates Induce Defense Priming Against Bacteria in Arabidopsis thaliana
por: Balmer, Andrea, et al.
Publicado: (2018)

Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of Immune Responses
por: Choi, Inseok, et al.
Publicado: (2021)

Signals from the Circle: Tricarboxylic Acid Cycle Intermediates as Myometabokines
por: Maurer, Jennifer, et al.
Publicado: (2021)

Systemic alterations of tricarboxylic acid cycle enzymes in Alzheimer’s disease
por: Jia, Dongdong, et al.
Publicado: (2023)

Reduced tricarboxylic acid cycle flux in type 2 diabetes mellitus?
por: Schrauwen, P., et al.
Publicado: (2008)

The Tricarboxylic Acid Cycle, an Ancient Metabolic Network with a Novel Twist
por: Mailloux, Ryan J., et al.
Publicado: (2007)

Rapid determination of tricarboxylic acid cycle enzyme activities in biological samples
por: Goncalves, Sergio, et al.
Publicado: (2010)

Evolution and Functional Implications of the Tricarboxylic Acid Cycle as Revealed by Phylogenetic Analysis
por: Cavalcanti, João Henrique Frota, et al.
Publicado: (2014)

Protein-protein interactions and metabolite channelling in the plant tricarboxylic acid cycle
por: Zhang, Youjun, et al.
Publicado: (2017)

Breaking the cycle: Reversal of flux in the tricarboxylic acid cycle by dimethyl fumarate
por: Gafson, Arie R., et al.
Publicado: (2019)

Therapeutic potential of tricarboxylic acid cycle metabolite itaconate in cardiovascular diseases
por: Yang, Chongzhe, et al.
Publicado: (2020)

Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells
por: Zalis, Eliza A., et al.
Publicado: (2019)

Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury
por: Cordes, Thekla, et al.
Publicado: (2019)

Glucocorticoids coordinate macrophage metabolism through the regulation of the tricarboxylic acid cycle
por: Stifel, Ulrich, et al.
Publicado: (2021)

Disruption of the MreB Elongasome Is Overcome by Mutations in the Tricarboxylic Acid Cycle
por: Barton, Brody, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_487666agr6ikrrdn47ltumjq9g