Binding of the erlin1/2 complex to the third intralumenal loop of IP(3)R1 triggers its ubiquitin-proteasomal degradation

Long-term activation of inositol 1,4,5-trisphosphate receptors (IP(3)Rs) leads to their degradation by the ubiquitin–proteasome pathway. The first and rate-limiting step in this process is thought to be the association of conformationally active IP(3)Rs with the erlin1/2 complex, an endoplasmic reti...

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Detalles Bibliográficos
Autores principales: Gao, Xiaokong, Bonzerato, Caden G., Wojcikiewicz, Richard J.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168715/
https://www.ncbi.nlm.nih.gov/pubmed/35568199
http://dx.doi.org/10.1016/j.jbc.2022.102026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168715/
https://www.ncbi.nlm.nih.gov/pubmed/35568199
http://dx.doi.org/10.1016/j.jbc.2022.102026

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