Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction

Iron surface determinant B (IsdB) is a hemoglobin (Hb) receptor essential for hemic iron acquisition by Staphylococcus aureus. Heme transfer to IsdB is possible from oxidized Hb (metHb), but inefficient from Hb either bound to oxygen (oxyHb) or bound to carbon monoxide (HbCO), and encompasses a sequ...

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Detalles Bibliográficos
Autores principales: De Bei, Omar, Marchetti, Marialaura, Ronda, Luca, Gianquinto, Eleonora, Lazzarato, Loretta, Chirgadze, Dimitri Y., Hardwick, Steven W., Cooper, Lee R., Spyrakis, Francesca, Luisi, Ben F., Campanini, Barbara, Bettati, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168843/
https://www.ncbi.nlm.nih.gov/pubmed/35357971
http://dx.doi.org/10.1073/pnas.2116708119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168843/
https://www.ncbi.nlm.nih.gov/pubmed/35357971
http://dx.doi.org/10.1073/pnas.2116708119

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