50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA

Changes in bacterial ribosomal RNA (rRNA) methylation status can alter the activity of diverse groups of ribosome-targeting antibiotics. These modifications are typically incorporated by a single methyltransferase that acts on one nucleotide target and rRNA methylation directly prevents drug binding...

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Detalles Bibliográficos
Autores principales: Laughlin, Zane T., Nandi, Suparno, Dey, Debayan, Zelinskaya, Natalia, Witek, Marta A., Srinivas, Pooja, Nguyen, Ha An, Kuiper, Emily G., Comstock, Lindsay R., Dunham, Christine M., Conn, Graeme L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168844/
https://www.ncbi.nlm.nih.gov/pubmed/35357969
http://dx.doi.org/10.1073/pnas.2120352119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168844/
https://www.ncbi.nlm.nih.gov/pubmed/35357969
http://dx.doi.org/10.1073/pnas.2120352119

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