Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding

The human P4 ATPase ATP8B1 in complex with the auxiliary noncatalytic protein CDC50A or CDC50B mediates the transport of cell-membrane lipids from the outer to the inner membrane leaflet, which is crucial to maintain the asymmetry of membrane lipids. Its dysfunction usually leads to an imbalance of...

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Detalles Bibliográficos
Autores principales: Cheng, Meng-Ting, Chen, Yu, Chen, Zhi-Peng, Liu, Xin, Zhang, Zhiyong, Chen, Yuxing, Hou (侯文韬), Wen-Tao, Zhou, Cong-Zhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168909/
https://www.ncbi.nlm.nih.gov/pubmed/35349344
http://dx.doi.org/10.1073/pnas.2118656119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168909/
https://www.ncbi.nlm.nih.gov/pubmed/35349344
http://dx.doi.org/10.1073/pnas.2118656119

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