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Human cytomegalovirus lytic infection inhibits replication-dependent histone synthesis and requires stem loop binding protein function
Replication-dependent (RD) histones are deposited onto human cytomegalovirus (HCMV) genomes at the start of infection. We examined how HCMV affects the de novo production of RD histones and found that viral infection blocked the accumulation of RD histone mRNAs that normally occurs during the S phas...
Autores principales: | Albright, Emily R., Morrison, Kylee, Ranganathan, Padhma, Carter, Dominique M., Nishikiori, Masaki, Lee, Jeong-Hee, Slayton, Mark D., Ahlquist, Paul, Terhune, Scott S., Kalejta, Robert F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169081/ https://www.ncbi.nlm.nih.gov/pubmed/35344424 http://dx.doi.org/10.1073/pnas.2122174119 |
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