Further Evidence that Inhibition of Neuronal Voltage-Gated Calcium Channels Contributes to the Hypnotic Effect of Neurosteroid Analogue, 3β-OH

We recently reported that a neurosteroid analogue with T-channel-blocking properties (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH), induced hypnosis in rat pups without triggering neuronal apoptosis. Furthermore, we found that the inhibition of the Ca(V)3.1 isoform of T-channels contribute...

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Detalles Bibliográficos
Autores principales: Timic Stamenic, Tamara, Manzella, Francesca M., Maksimovic, Stefan, Krishnan, Kathiresan, Covey, Douglas F., Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169093/
https://www.ncbi.nlm.nih.gov/pubmed/35677453
http://dx.doi.org/10.3389/fphar.2022.850658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169093/
https://www.ncbi.nlm.nih.gov/pubmed/35677453
http://dx.doi.org/10.3389/fphar.2022.850658

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