Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis

Glycosylphosphatidylinositols (GPIs) are complex glycolipids that act as membrane anchors of many eukaryotic cell surface proteins. Biosynthesis of GPIs is initiated at the cytosolic face of the endoplasmic reticulum (ER) by generation of N-acetylglucosaminyl-phosphatidylinositol (GlcNAc-PI). The se...

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Detalles Bibliográficos
Autores principales: Wang, Yicheng, Menon, Anant K., Maki, Yuta, Liu, Yi-Shi, Iwasaki, Yugo, Fujita, Morihisa, Guerrero, Paula A., Silva, Daniel Varó’n, Seeberger, Peter H., Murakami, Yoshiko, Kinoshita, Taroh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169118/
https://www.ncbi.nlm.nih.gov/pubmed/35344438
http://dx.doi.org/10.1073/pnas.2115083119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169118/
https://www.ncbi.nlm.nih.gov/pubmed/35344438
http://dx.doi.org/10.1073/pnas.2115083119

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