Impedance-Based Phenotypic Readout of Transporter Function: A Case for Glutamate Transporters

Excitatory amino acid transporters (EAAT/SLC1) mediate Na(+)-dependent uptake of extracellular glutamate and are potential drug targets for neurological disorders. Conventional methods to assess glutamate transport in vitro are based on radiolabels, fluorescent dyes or electrophysiology, which poten...

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Detalles Bibliográficos
Autores principales: Sijben, Hubert J., Dall’ Acqua, Laura, Liu, Rongfang, Jarret, Abigail, Christodoulaki, Eirini, Onstein, Svenja, Wolf, Gernot, Verburgt, Simone J., Le Dévédec, Sylvia E., Wiedmer, Tabea, Superti-Furga, Giulio, IJzerman, Adriaan P., Heitman, Laura H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169222/
https://www.ncbi.nlm.nih.gov/pubmed/35677430
http://dx.doi.org/10.3389/fphar.2022.872335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169222/
https://www.ncbi.nlm.nih.gov/pubmed/35677430
http://dx.doi.org/10.3389/fphar.2022.872335

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