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A qPCR-Based Method for Quantification of RCA Contaminants in Oncolytic Adenovirus Products
Oncolytic adenovirus is one of the most promising treatments against cancer and is widely evaluated clinically. During high titer production, “Wild-type-” like replication-competent adenovirus (RCA) contaminants can be generated through recombination events due to the DNA sequence similarity between...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169249/ https://www.ncbi.nlm.nih.gov/pubmed/35677885 http://dx.doi.org/10.3389/fmolb.2022.883249 |