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A qPCR-Based Method for Quantification of RCA Contaminants in Oncolytic Adenovirus Products

Oncolytic adenovirus is one of the most promising treatments against cancer and is widely evaluated clinically. During high titer production, “Wild-type-” like replication-competent adenovirus (RCA) contaminants can be generated through recombination events due to the DNA sequence similarity between...

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Detalles Bibliográficos
Autores principales:	Gao, Menghan, Yngve, Erik, Yu, Di, Jin, Chuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169249/ https://www.ncbi.nlm.nih.gov/pubmed/35677885 http://dx.doi.org/10.3389/fmolb.2022.883249

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