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RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells
Rationale: PI3K/mTOR signaling is frequently upregulated in breast cancer making inhibitors of this pathway highly promising anticancer drugs. However, PI3K-inhibitors have a low therapeutic index. Therefore, finding novel combinatory treatment options represents an important step towards clinical i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169373/ https://www.ncbi.nlm.nih.gov/pubmed/35673573 http://dx.doi.org/10.7150/thno.68299 |