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Detection of increased pyruvate dehydrogenase flux in the human heart during adenosine stress test using hyperpolarized [1-(13)C]pyruvate cardiovascular magnetic resonance imaging

BACKGROUND: Hyperpolarized (HP) [1-(13)C]pyruvate cardiovascular magnetic resonance (CMR) imaging can visualize the uptake and intracellular conversion of [1-(13)C]pyruvate to either [1-(13)C]lactate or (13)C-bicarbonate depending on the prevailing metabolic state. The aim of the present study was t...

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Detalles Bibliográficos
Autores principales: Joergensen, Steen Hylgaard, Hansen, Esben Soevsoe S., Bøgh, Nikolaj, Bertelsen, Lotte Bonde, Staehr, Peter Bisgaard, Schulte, Rolf F., Malloy, Craig, Wiggers, Henrik, Laustsen, Christoffer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169396/
https://www.ncbi.nlm.nih.gov/pubmed/35658896
http://dx.doi.org/10.1186/s12968-022-00860-6