Decrypting a cryptic allosteric pocket in H. pylori glutamate racemase

One of our greatest challenges in drug design is targeting cryptic allosteric pockets in enzyme targets. Drug leads that do bind to these cryptic pockets are often discovered during HTS campaigns, and the mechanisms of action are rarely understood. Nevertheless, it is often the case that the alloste...

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Detalles Bibliográficos
Autores principales: Chheda, Pratik Rajesh, Cooling, Grant T., Dean, Sondra F., Propp, Jonah, Hobbs, Kathryn F., Spies, M. Ashley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169614/
https://www.ncbi.nlm.nih.gov/pubmed/35673630
http://dx.doi.org/10.1038/s42004-021-00605-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169614/
https://www.ncbi.nlm.nih.gov/pubmed/35673630
http://dx.doi.org/10.1038/s42004-021-00605-z

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