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Massively parallel, computationally guided design of a proenzyme

Confining the activity of a designed protein to a specific microenvironment would have broad-ranging applications, such as enabling cell type-specific therapeutic action by enzymes while avoiding off-target effects. While many natural enzymes are synthesized as inactive zymogens that can be activate...

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Detalles Bibliográficos
Autores principales: Yachnin, Brahm J., Azouz, Laura R., White, Ralph E., Minetti, Conceição A. S. A., Remeta, David P., Tan, Victor M., Drake, Justin M., Khare, Sagar D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169645/
https://www.ncbi.nlm.nih.gov/pubmed/35377786
http://dx.doi.org/10.1073/pnas.2116097119