Metabolic reprogramming of tumor-associated macrophages by collagen turnover promotes fibrosis in pancreatic cancer

A hallmark of pancreatic tumors is their highly desmoplastic stroma composed of fibroblasts, immune cells, and a dense network of collagen fibers. Tumor-associated macrophages are one of the most abundant immune cell populations in the pancreatic tumor stroma. Their protumorigenic function has been...

Descripción completa

Detalles Bibliográficos
Autores principales: LaRue, Madeleine M., Parker, Seth, Puccini, Joseph, Cammer, Michael, Kimmelman, Alec C., Bar-Sagi, Dafna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169723/
https://www.ncbi.nlm.nih.gov/pubmed/35412885
http://dx.doi.org/10.1073/pnas.2119168119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169723/
https://www.ncbi.nlm.nih.gov/pubmed/35412885
http://dx.doi.org/10.1073/pnas.2119168119

Ejemplares similares