Chemical–genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy

Current chemotherapy against Mycobacterium tuberculosis (Mtb), an important human pathogen, requires a multidrug regimen lasting several months. While efforts have been made to optimize therapy by exploiting drug–drug synergies, testing new drug combinations in relevant host environments remains ard...

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Detalles Bibliográficos
Autores principales: Koh, Eun-Ik, Oluoch, Peter O., Ruecker, Nadine, Proulx, Megan K., Soni, Vijay, Murphy, Kenan C., Papavinasasundaram, Kadamba, Reames, Charlotte J., Trujillo, Carolina, Zaveri, Anisha, Zimmerman, Matthew D., Aslebagh, Roshanak, Baker, Richard E., Shaffer, Scott A., Guinn, Kristine M., Fitzgerald, Michael, Dartois, Véronique, Ehrt, Sabine, Hung, Deborah T., Ioerger, Thomas R., Rubin, Eric J., Rhee, Kyu Y., Schnappinger, Dirk, Sassetti, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169745/
https://www.ncbi.nlm.nih.gov/pubmed/35380903
http://dx.doi.org/10.1073/pnas.2201632119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169745/
https://www.ncbi.nlm.nih.gov/pubmed/35380903
http://dx.doi.org/10.1073/pnas.2201632119

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