GPCR large-amplitude dynamics by (19)F-NMR of aprepitant bound to the neurokinin 1 receptor

Comparisons of G protein-coupled receptor (GPCR) complexes with agonists and antagonists based on X-ray crystallography and cryo-electron microscopy structure determinations show differences in the width of the orthosteric ligand binding groove over the range from 0.3 to 2.9 Å. Here, we show that th...

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Detalles Bibliográficos
Autores principales: Pan, Benxun, Liu, Dongsheng, Yang, Lingyun, Wüthrich, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169749/
https://www.ncbi.nlm.nih.gov/pubmed/35377814
http://dx.doi.org/10.1073/pnas.2122682119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169749/
https://www.ncbi.nlm.nih.gov/pubmed/35377814
http://dx.doi.org/10.1073/pnas.2122682119

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