Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation

In neurodegenerative diseases including Alzheimer’s and amyotrophic lateral sclerosis, proteins that bind RNA are found in aggregated forms in autopsied brains. Evidence suggests that RNA aids nucleation of these pathological aggregates; however, the mechanism has not been investigated at the level...

Descripción completa

Detalles Bibliográficos
Autores principales: Abskharon, Romany, Sawaya, Michael R., Boyer, David R., Cao, Qin, Nguyen, Binh A., Cascio, Duilio, Eisenberg, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169762/
https://www.ncbi.nlm.nih.gov/pubmed/35377792
http://dx.doi.org/10.1073/pnas.2119952119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169762/
https://www.ncbi.nlm.nih.gov/pubmed/35377792
http://dx.doi.org/10.1073/pnas.2119952119

Ejemplares similares