STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy

In idiopathic Parkinson’s disease (PD), pathologic αSyn aggregates drive oxidative and nitrative stress that may cause genomic and mitochondrial DNA damage. These events are associated with activation of the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) immune pathway, but it...

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Detalles Bibliográficos
Autores principales: Hinkle, Jared T., Patel, Jaimin, Panicker, Nikhil, Karuppagounder, Senthilkumar S., Biswas, Devanik, Belingon, Bonn, Chen, Rong, Brahmachari, Saurav, Pletnikova, Olga, Troncoso, Juan C., Dawson, Valina L., Dawson, Ted M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169780/
https://www.ncbi.nlm.nih.gov/pubmed/35394877
http://dx.doi.org/10.1073/pnas.2118819119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169780/
https://www.ncbi.nlm.nih.gov/pubmed/35394877
http://dx.doi.org/10.1073/pnas.2118819119

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