Advanced age increases frequencies of de novo mitochondrial mutations in macaque oocytes and somatic tissues

Mutations in mitochondrial DNA (mtDNA) contribute to multiple diseases. However, how new mtDNA mutations arise and accumulate with age remains understudied because of the high error rates of current sequencing technologies. Duplex sequencing reduces error rates by several orders of magnitude via ind...

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Detalles Bibliográficos
Autores principales: Arbeithuber, Barbara, Cremona, Marzia A., Hester, James, Barrett, Alison, Higgins, Bonnie, Anthony, Kate, Chiaromonte, Francesca, Diaz, Francisco J., Makova, Kateryna D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169796/
https://www.ncbi.nlm.nih.gov/pubmed/35394879
http://dx.doi.org/10.1073/pnas.2118740119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169796/
https://www.ncbi.nlm.nih.gov/pubmed/35394879
http://dx.doi.org/10.1073/pnas.2118740119

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