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Advanced age increases frequencies of de novo mitochondrial mutations in macaque oocytes and somatic tissues
Mutations in mitochondrial DNA (mtDNA) contribute to multiple diseases. However, how new mtDNA mutations arise and accumulate with age remains understudied because of the high error rates of current sequencing technologies. Duplex sequencing reduces error rates by several orders of magnitude via ind...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169796/ https://www.ncbi.nlm.nih.gov/pubmed/35394879 http://dx.doi.org/10.1073/pnas.2118740119 |