LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation

Cancer and chronic infections often increase levels of the bioactive lipid, lysophosphatidic acid (LPA), that we have demonstrated acts as an inhibitory ligand upon binding LPAR5 on CD8 T cells, suppressing cytotoxic activity and tumor control. This study, using human and mouse primary T lymphocytes...

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Detalles Bibliográficos
Autores principales: Kremer, Kimberly N., Buser, Alan, Thumkeo, Dean, Narumiya, Shuh, Jacobelli, Jordan, Pelanda, Roberta, Torres, Raul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169816/
https://www.ncbi.nlm.nih.gov/pubmed/35394866
http://dx.doi.org/10.1073/pnas.2118816119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169816/
https://www.ncbi.nlm.nih.gov/pubmed/35394866
http://dx.doi.org/10.1073/pnas.2118816119

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