The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio

Hypocretin (Hcrt), also known as orexin, neuropeptide signaling stabilizes sleep and wakefulness in all vertebrates. A lack of Hcrt causes the sleep disorder narcolepsy, and increased Hcrt signaling has been speculated to cause insomnia, but while the signaling pathways of Hcrt are relatively well-d...

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Detalles Bibliográficos
Autores principales: Holm, Anja, Possovre, Marie-Laure, Bandarabadi, Mojtaba, Moseholm, Kristine F., Justinussen, Jessica L., Bozic, Ivan, Lemcke, René, Arribat, Yoan, Amati, Francesca, Silahtaroglu, Asli, Juventin, Maxime, Adamantidis, Antoine, Tafti, Mehdi, Kornum, Birgitte R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169915/
https://www.ncbi.nlm.nih.gov/pubmed/35452310
http://dx.doi.org/10.1073/pnas.2112225119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169915/
https://www.ncbi.nlm.nih.gov/pubmed/35452310
http://dx.doi.org/10.1073/pnas.2112225119

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