Cargando…

Structural and functional insight into mismatch extension by human DNA polymerase α

Human DNA polymerase α (Polα) does not possess proofreading ability and plays an important role in genome replication and mutagenesis. Polα extends the RNA primers generated by primase and provides a springboard for loading other replication factors. Here we provide the structural and functional ana...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baranovskiy, Andrey G., Babayeva, Nigar D., Lisova, Alisa E., Morstadt, Lucia M., Tahirov, Tahir H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169922/ https://www.ncbi.nlm.nih.gov/pubmed/35467978 http://dx.doi.org/10.1073/pnas.2111744119

Ejemplares similares

Human DNA polymerase α has a strong mutagenic potential at the initial steps of DNA synthesis
por: Lisova, Alisa E, et al.
Publicado: (2022)

Efficient discrimination against RNA-containing primers by human DNA polymerase ε
por: Lisova, Alisa E., et al.
Publicado: (2022)

Insight into RNA–DNA primer length counting by human primosome
por: Baranovskiy, Andrey G, et al.
Publicado: (2022)

The iron-sulfur cluster is essential for DNA binding by human DNA polymerase ε
por: Lisova, Alisa E., et al.
Publicado: (2022)

Structural basis for inhibition of DNA replication by aphidicolin
por: Baranovskiy, Andrey G., et al.
Publicado: (2014)

Structural Basis of Ets1 Cooperative Binding to Widely Separated Sites on Promoter DNA
por: Babayeva, Nigar D., et al.
Publicado: (2012)

Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase δ mutation in human cells
por: Mertz, Tony M., et al.
Publicado: (2017)

Elaborated Action of the Human Primosome
por: Baranovskiy, Andrey G., et al.
Publicado: (2017)

Functional mapping of the fission yeast DNA polymerase δ B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis
por: Sanchez Garcia, Javier, et al.
Publicado: (2009)

Structural basis of Ets1 activation by Runx1
por: Shrivastava, Tripti, et al.
Publicado: (2014)

Promiscuous mismatch extension by human DNA polymerase lambda
por: Picher, Angel J., et al.
Publicado: (2006)

Crystal structure of HIV-1 Tat complexed with human P-TEFb
por: Tahirov, Tahir H., et al.
Publicado: (2010)

DNA primase large subunit is an essential plant gene for geminiviruses, putatively priming viral ss-DNA replication
por: Siskos, Lampros, et al.
Publicado: (2023)

The role of catalytic and regulatory domains of human PrimPol in DNA binding and synthesis
por: Boldinova, Elizaveta O, et al.
Publicado: (2023)

Translesion activity of PrimPol on DNA with cisplatin and DNA–protein cross-links
por: Boldinova, Elizaveta O., et al.
Publicado: (2021)

DNA polymerase δ proofreads errors made by DNA polymerase ε
por: Bulock, Chelsea R., et al.
Publicado: (2020)

The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β
por: Koag, Myong-Chul, et al.
Publicado: (2014)

Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol ε and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors
por: Tahirov, Tahir H, et al.
Publicado: (2009)

The structural impact of DNA mismatches
por: Rossetti, Giulia, et al.
Publicado: (2015)

Structure of eukaryotic DNA polymerase δ bound to the PCNA clamp while encircling DNA
por: Zheng, Fengwei, et al.
Publicado: (2020)

Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase
por: Lelyveld, Victor S., et al.
Publicado: (2020)

Variants of sequence family B Thermococcus kodakaraensis DNA polymerase with increased mismatch extension selectivity
por: Huber, Claudia, et al.
Publicado: (2017)

The mismatch recognition protein MutSα promotes nascent strand degradation at stalled replication forks
por: Zhang, Junqiu, et al.
Publicado: (2022)

New insights into the structures and interactions of bacterial Y-family DNA polymerases
por: Timinskas, Kęstutis, et al.
Publicado: (2019)

Mismatched dNTP incorporation by DNA polymerase β does not proceed via globally different conformational pathways(†)
por: Tang, Kuo-Hsiang, et al.
Publicado: (2008)

Mechanism of RNA polymerase II stalling by DNA alkylation
por: Malvezzi, Stefano, et al.
Publicado: (2017)

Inaccurate DNA Synthesis in Cell Extracts of Yeast Producing Active Human DNA Polymerase Iota
por: Makarova, Alena V., et al.
Publicado: (2011)

Direct visualization of translesion DNA synthesis polymerase IV at the replisome
por: Tuan, Pham Minh, et al.
Publicado: (2022)

Structural insights into α-synuclein monomer–fibril interactions
por: Kumari, Pratibha, et al.
Publicado: (2021)

Mechanism for priming DNA synthesis by yeast DNA Polymerase α
por: Perera, Rajika L, et al.
Publicado: (2013)

HDAC3 deacetylates the DNA mismatch repair factor MutSβ to stimulate triplet repeat expansions
por: Williams, Gregory M., et al.
Publicado: (2020)

Interlocking activities of DNA polymerase β in the base excision repair pathway
por: Kumar, Adarsh, et al.
Publicado: (2022)

Human DNA mismatch repair: coupling of mismatch recognition to strand-specific excision
por: Wang, Huixian, et al.
Publicado: (2007)

Mutations in the MutSα interaction interface of MLH1 can abolish DNA mismatch repair
por: Plotz, Guido, et al.
Publicado: (2006)

Snapshots of a modified nucleotide moving through the confines of a DNA polymerase
por: Kropp, Heike Maria, et al.
Publicado: (2018)

Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic
por: Cholewa-Waclaw, Justyna, et al.
Publicado: (2019)

Global genomic instability caused by reduced expression of DNA polymerase ε in yeast
por: Zhang, Ke, et al.
Publicado: (2022)

Analysis of APOBEC-induced mutations in yeast strains with low levels of replicative DNA polymerases
por: Sui, Yang, et al.
Publicado: (2020)

The Paf1 complex is required for RNA polymerase II removal in response to DNA damage
por: Chen, Feilong, et al.
Publicado: (2022)

Solution structure and stability of the DNA undecamer duplexes containing oxanine mismatch
por: Pack, Seung Pil, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_8tb5j5laodarl1r6suh7md53cr