FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids

Iron-dependent peroxidation of polyunsaturated fatty acids (PUFAs) leads to ferroptosis. While detoxification reactions removing lipid peroxides in phospholipids such as that catalyzed by glutathione peroxidase 4 (GPX4) protect cells from ferroptosis, the mechanism through which cells prevent PUFA p...

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Detalles Bibliográficos
Autores principales: Cui, Shaojie, Simmons, Glenn, Vale, Goncalo, Deng, Yaqin, Kim, Jungyeon, Kim, Hyeonwoo, Zhang, Ruihui, McDonald, Jeffrey G., Ye, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169925/
https://www.ncbi.nlm.nih.gov/pubmed/35467977
http://dx.doi.org/10.1073/pnas.2107189119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169925/
https://www.ncbi.nlm.nih.gov/pubmed/35467977
http://dx.doi.org/10.1073/pnas.2107189119

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