Cargando…

FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids

Iron-dependent peroxidation of polyunsaturated fatty acids (PUFAs) leads to ferroptosis. While detoxification reactions removing lipid peroxides in phospholipids such as that catalyzed by glutathione peroxidase 4 (GPX4) protect cells from ferroptosis, the mechanism through which cells prevent PUFA p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cui, Shaojie, Simmons, Glenn, Vale, Goncalo, Deng, Yaqin, Kim, Jungyeon, Kim, Hyeonwoo, Zhang, Ruihui, McDonald, Jeffrey G., Ye, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169925/ https://www.ncbi.nlm.nih.gov/pubmed/35467977 http://dx.doi.org/10.1073/pnas.2107189119

Ejemplares similares

Polyunsaturated Fatty Acids Drive Lipid Peroxidation during Ferroptosis
por: Mortensen, Michael S., et al.
Publicado: (2023)

Perfluoro Allyl Fluorosulfate (FAFS): A Versatile Building Block for New Fluoroallylic Compounds
por: Wlassics, Ivan, et al.
Publicado: (2011)

Polyunsaturated Fatty Acid Dietary Supplementation Induces Lipid Peroxidation in Normal Dogs
por: Walters, John M., et al.
Publicado: (2010)

FAF-Drugs: free ADME/tox filtering of compound collections
por: Miteva, Maria A., et al.
Publicado: (2006)

Molecular Analysis of a Recurrent Sarcoma Identifies a Mutation in FAF1
por: Weber, Georg F.
Publicado: (2015)

A novel function of FAF1, which induces dopaminergic neuronal death through cell-to-cell transmission
por: Park, Gyeongrin, et al.
Publicado: (2020)

Insights into the role of oxidative stress in the pathology of Friedreich ataxia using peroxidation resistant polyunsaturated fatty acids
por: Cotticelli, M. Grazia, et al.
Publicado: (2013)

Reduced FAF1 Expression and Helicobacter Infection: Correlations with Clinicopathological Features in Gastric Cancer
por: Liu, Ai-qun, et al.
Publicado: (2012)

Analysis on the Expression and Prognostic Value of LncRNA FAF in Patients with Coronary Heart Disease
por: Xu, Hai, et al.
Publicado: (2020)

Ferroptosis by Lipid Peroxidation: The Tip of the Iceberg?
por: Chen, Xin, et al.
Publicado: (2021)

Mitochondrial Lipid Peroxidation Is Responsible for Ferroptosis
por: Lyamzaev, Konstantin G., et al.
Publicado: (2023)

Five Decades with Polyunsaturated Fatty Acids: Chemical Synthesis, Enzymatic Formation, Lipid Peroxidation and Its Biological Effects
por: Catalá, Angel
Publicado: (2013)

FAF-Drugs3: a web server for compound property calculation and chemical library design
por: Lagorce, David, et al.
Publicado: (2015)

USP7 and VCP(FAF1) define the SUMO/Ubiquitin landscape at the DNA replication fork
por: Franz, André, et al.
Publicado: (2021)

Fatigue assessment by FACIT-F scale in Pakistani cohort with Rheumatoid Arthritis (FAF-RA) study
por: Wagan, Abrar Ahmed, et al.
Publicado: (2021)

Mendelian Randomization Analysis Reveals Causal Effects of Polyunsaturated Fatty Acids on Subtypes of Diabetic Retinopathy Risk
por: Ren, Shaojie, et al.
Publicado: (2023)

Narrative Review of n-3 Polyunsaturated Fatty Acid Supplementation upon Immune Functions, Resolution Molecules and Lipid Peroxidation
por: Zaloga, Gary P.
Publicado: (2021)

Regulation of lipid peroxidation and ferroptosis in diverse species
por: Conrad, Marcus, et al.
Publicado: (2018)

ROS induced lipid peroxidation and their role in ferroptosis
por: Endale, Hiwot Tezera, et al.
Publicado: (2023)

TXNDC12 inhibits lipid peroxidation and ferroptosis
por: Tang, Lanlan, et al.
Publicado: (2023)

Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure
por: Yamada, Naoya, et al.
Publicado: (2020)

Polyunsaturated Fatty Acids in Children
por: Lee, Ji-Hyuk
Publicado: (2013)

Convergent and Stereospecific Synthesis of Complex Skipped Polyenes and Polyunsaturated Fatty Acids
por: Macklin, Todd K., et al.
Publicado: (2010)

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
por: Franz, André, et al.
Publicado: (2016)

FAF1 downregulation by Toxoplasma gondii enables host IRF3 mobilization and promotes parasite growth
por: Gao, Fei‐Fei, et al.
Publicado: (2021)

Peroxidation of n-3 Polyunsaturated Fatty Acids Inhibits the Induction of iNOS Gene Expression in Proinflammatory Cytokine-Stimulated Hepatocytes
por: Araki, Yoshiro, et al.
Publicado: (2011)

Antioxidants help favorably regulate the kinetics of lipid peroxidation, polyunsaturated fatty acids degradation and acidic cannabinoids decarboxylation in hempseed oil
por: Pratap Singh, Anubhav, et al.
Publicado: (2020)

Heterologous Reconstitution of Omega-3 Polyunsaturated Fatty Acids in Arabidopsis
por: Kim, Sun Hee, et al.
Publicado: (2015)

Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals
por: Barayeu, Uladzimir, et al.
Publicado: (2022)

Ferroptosis: whERe is the critical site of lipid peroxidation?
por: Yang, Wan Seok
Publicado: (2023)

FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects
por: Lagorce, David, et al.
Publicado: (2008)

The p97-FAF1 Protein Complex Reveals a Common Mode of p97 Adaptor Binding
por: Ewens, Caroline A., et al.
Publicado: (2014)

Erratum: Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
por: Franz, André, et al.
Publicado: (2016)

FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis
por: Xie, Feng, et al.
Publicado: (2017)

Serum Circ‐FAF1/Circ‐ELP3: A novel potential biomarker for breast cancer diagnosis
por: Omid‐Shafaat, Ramtin, et al.
Publicado: (2021)

Lipidomics of oxidized polyunsaturated fatty acids
por: Massey, Karen A., et al.
Publicado: (2013)

FAF1 mediates necrosis through JNK1-mediated mitochondrial dysfunction leading to retinal degeneration in the ganglion cell layer upon ischemic insult
por: Yu, Changsun, et al.
Publicado: (2018)

miR-24 Regulates Apoptosis by Targeting the Open Reading Frame (ORF) Region of FAF1 in Cancer Cells
por: Qin, Wenming, et al.
Publicado: (2010)

Modification of α-synuclein by lipid peroxidation products derived from polyunsaturated fatty acids promotes toxic oligomerization: its relevance to Parkinson disease
por: Shamoto-Nagai, Masayo, et al.
Publicado: (2018)

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection
por: Matsushita, Mai, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_34liq9b6pq6uio0ecu7mrq9rhf