Origin of iodine preferential attack at sulfur in phosphorothioate and subsequent P-O or P-S bond dissociation

Iodine-induced cleavage at phosphorothioate DNA (PT-DNA) is characterized by extremely high sensitivity (∼1 phosphorothioate link per 10(6) nucleotides), which has been used for detecting and sequencing PT-DNA in bacteria. Despite its foreseeable potential for wide applications, the cleavage mechani...

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Detalles Bibliográficos
Autores principales: Huang, Qiang, Lee, Ga Young, Li, Jiayi, Wang, Chuan, Zhao, Rosalinda L., Deng, Zixin, Houk, K. N., Zhao, Yi-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169930/
https://www.ncbi.nlm.nih.gov/pubmed/35439051
http://dx.doi.org/10.1073/pnas.2119032119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169930/
https://www.ncbi.nlm.nih.gov/pubmed/35439051
http://dx.doi.org/10.1073/pnas.2119032119

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