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Origin of iodine preferential attack at sulfur in phosphorothioate and subsequent P-O or P-S bond dissociation
Iodine-induced cleavage at phosphorothioate DNA (PT-DNA) is characterized by extremely high sensitivity (∼1 phosphorothioate link per 10(6) nucleotides), which has been used for detecting and sequencing PT-DNA in bacteria. Despite its foreseeable potential for wide applications, the cleavage mechani...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169930/ https://www.ncbi.nlm.nih.gov/pubmed/35439051 http://dx.doi.org/10.1073/pnas.2119032119 |