Antibody-mediated blockade of the IL23 receptor destabilizes intratumoral regulatory T cells and enhances immunotherapy

Regulatory T cells (Treg) can impede antitumor immunity and currently represent a major obstacle to effective cancer immunotherapy. Targeting tumor-infiltrating regulatory Treg while sparing systemic Treg represents an optimal approach to this problem. Here, we provide evidence that the interleukin...

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Detalles Bibliográficos
Autores principales: Wight, Andrew E., Sido, Jessica M., Degryse, Sandrine, Ao, Lin, Nakagawa, Hidetoshi, Qiu(Vivian), Yiguo, Shen, Xianli, Oseghali, Oba, Kim, Hye-Jung, Cantor, Harvey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170135/
https://www.ncbi.nlm.nih.gov/pubmed/35482921
http://dx.doi.org/10.1073/pnas.2200757119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170135/
https://www.ncbi.nlm.nih.gov/pubmed/35482921
http://dx.doi.org/10.1073/pnas.2200757119

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