Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells

Multiple membrane organelles require cholesterol for proper function within cells. The Niemann-Pick type C (NPC) proteins export cholesterol from endosomes to other membrane compartments, including the endoplasmic reticulum (ER), plasma membrane (PM), trans-Golgi network (TGN), and mitochondria, to...

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Detalles Bibliográficos
Autores principales: Rogers, Maximillian A., Chang, Catherine C. Y., Maue, Robert A., Melton, Elaina M., Peden, Andrew A., Garver, William S., Lee, Junghoon, Schroen, Peter, Huang, Mitchell, Chang, Ta-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170141/
https://www.ncbi.nlm.nih.gov/pubmed/35507892
http://dx.doi.org/10.1073/pnas.2201646119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170141/
https://www.ncbi.nlm.nih.gov/pubmed/35507892
http://dx.doi.org/10.1073/pnas.2201646119

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