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Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells

Multiple membrane organelles require cholesterol for proper function within cells. The Niemann-Pick type C (NPC) proteins export cholesterol from endosomes to other membrane compartments, including the endoplasmic reticulum (ER), plasma membrane (PM), trans-Golgi network (TGN), and mitochondria, to...

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Detalles Bibliográficos
Autores principales:	Rogers, Maximillian A., Chang, Catherine C. Y., Maue, Robert A., Melton, Elaina M., Peden, Andrew A., Garver, William S., Lee, Junghoon, Schroen, Peter, Huang, Mitchell, Chang, Ta-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170141/ https://www.ncbi.nlm.nih.gov/pubmed/35507892 http://dx.doi.org/10.1073/pnas.2201646119

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