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Systems biology approach to functionally assess the Clostridioides difficile pangenome reveals genetic diversity with discriminatory power
Combatting Clostridioides difficile infections, a dominant cause of hospital-associated infections with incidence and resulting deaths increasing worldwide, is complicated by the frequent emergence of new virulent strains. Here, we employ whole-genome sequencing, high-throughput phenotypic screening...
Autores principales: | Norsigian, Charles J., Danhof, Heather A., Brand, Colleen K., Midani, Firas S., Broddrick, Jared T., Savidge, Tor C., Britton, Robert A., Palsson, Bernhard O., Spinler, Jennifer K., Monk, Jonathan M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170149/ https://www.ncbi.nlm.nih.gov/pubmed/35476524 http://dx.doi.org/10.1073/pnas.2119396119 |
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