RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice

Null mutations of spliceosome components or cofactors are homozygous lethal in eukaryotes, but viable hypomorphic mutations provide an opportunity to understand the physiological impact of individual splicing proteins. We describe a viable missense allele (F181I) of Rnps1 encoding an essential regul...

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Detalles Bibliográficos
Autores principales: Zhong, Xue, Choi, Jin Huk, Hildebrand, Sara, Ludwig, Sara, Wang, Jianhui, Nair-Gill, Evan, Liao, Tzu-Chieh, Moresco, James J., Liu, Aijie, Quan, Jiexia, Sun, Qihua, Zhang, Duanwu, Zhan, Xiaoming, Choi, Mihwa, Li, Xiaohong, Wang, Junmei, Gallagher, Thomas, Moresco, Eva Marie Y., Beutler, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170173/
https://www.ncbi.nlm.nih.gov/pubmed/35482923
http://dx.doi.org/10.1073/pnas.2200128119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170173/
https://www.ncbi.nlm.nih.gov/pubmed/35482923
http://dx.doi.org/10.1073/pnas.2200128119

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