Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs

The human genome encodes 850 G protein-coupled receptors (GPCRs), half of which are considered potential drug targets. GPCRs transduce extracellular stimuli into a plethora of vital physiological processes. Consequently, GPCRs are an attractive drug target class. This is underlined by the fact that...

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Detalles Bibliográficos
Autores principales: Laeremans, Toon, Sands, Zara A., Claes, Pieter, De Blieck, Ann, De Cesco, Stephane, Triest, Sarah, Busch, Andreas, Felix, David, Kumar, Abhinav, Jaakola, Veli-Pekka, Menet, Christel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170359/
https://www.ncbi.nlm.nih.gov/pubmed/35677880
http://dx.doi.org/10.3389/fmolb.2022.863099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170359/
https://www.ncbi.nlm.nih.gov/pubmed/35677880
http://dx.doi.org/10.3389/fmolb.2022.863099

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