The eIF4A Inhibitor Silvestrol Blocks the Growth of Human Glioblastoma Cells by Inhibiting AKT/mTOR and ERK1/2 Signaling Pathway

The most frequently identified central nervous system tumor in adults is glioblastoma multiforme (GBM). GBM prognosis remains poor despite multimodal treatment, i.e., surgery and radiation therapy with concurrent temozolomide-based chemotherapy. Silvestrol, an eIF4A inhibitor, has been demonstrated...

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Detalles Bibliográficos
Autores principales: Zhang, Wei, Gong, Pian, Tian, Qi, Han, Shoumeng, Wang, Jianfeng, He, Peibang, Guo, Yujia, Wang, Guijun, Chen, Qianxue, Huang, Jie, Li, Mingchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170441/
https://www.ncbi.nlm.nih.gov/pubmed/35677890
http://dx.doi.org/10.1155/2022/4396316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170441/
https://www.ncbi.nlm.nih.gov/pubmed/35677890
http://dx.doi.org/10.1155/2022/4396316

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